Published Models

BMP Signaling

Morpheus Model ID: M2982 Persistent identifier for this Morpheus model: Copy Spatio-temporal model of BMP signaling Introduction Juxtaposed sources of bone morphogenetic protein (BMP) and Nodal signaling molecules induce the formation of a full body axis in zebrafish embryos. Soh et al. studied body axis formation in zebrafish by transplanting signaling sources, specifically single clones expressing mouse BMP4 (mBMP4), and thereby inducing a secondary axis.

Tissue Size Control

Morpheus Model ID: M7990 Persistent identifier for this Morpheus model: Copy Bile Pressure Drives YAP Signaling During Liver Regeneration Introduction During development and regeneration, tissues must grow to the proper size. But tissue growth is just the result of independent cell cycle control systems in the individual cells. How does each cell sense the state of the tissue as a whole?

Liver Zonation

Morpheus Model ID: M6749 Persistent identifier for this Morpheus model: Copy Mutual Zonated Interactions of Wnt and Hh Signaling Are Orchestrating the Metabolism of the Adult Liver in Mice and Human Reference This model is described in the peer-reviewed publication: E. Kolbe, S. Aleithe, C. Rennert, L. Spormann, F. Ott, D. Meierhofer, R. Gajowski, C. Stöpel, S.

Planarian Regeneration (Double Head)

Morpheus Model ID: M0237 Persistent identifier for this Morpheus model: Copy Spatio-temporal model of planar polarity regulation during planarian regeneration Introduction This simulation reproduces Figure 4D of the referenced paper. Parameter values correspond to the β-catenin-1(RNAi) pattern as given in Table S2 of the referenced paper. Description The model explores the repolarization of the animal after the induction of an ectopic head.

Planarian Regeneration (Wild Type)

Morpheus Model ID: M7681 Persistent identifier for this Morpheus model: Copy Spatio-temporal model of planar polarity regulation during planarian regeneration Introduction This simulation reproduces Figure 4C of the referenced paper. Parameter values correspond to the wild type pattern (control) as given in Table S2 of the referenced paper. Description The model explores the establishment and stability of the wildtype polarity pattern.