Self-Organization

How does the architectural heterogeneity of the liver with its array of peri-central zones lead to the metabolic zonation across the liver lobule? Introduction Liver micro-architecture is set by an array of central veins interspersed with portal triads.

How does morphogen transport in a growing tissue feed back on tissue growth through morphogen signaling and cell division? Introduction The Drosophila wing primordium is a two-dimensional epithelial tissue that grows in response to the concentration profile of the morphogen Dpp (see Fig.

The formation of a flat and thin leaf presents a developmentally challenging problem, requiring intricate regulation of adaxial–abaxial …

A diffusible small-RNA-based Turing system dynamically coordinates organ polarity. Introduction The formation of a flat and thin leaf presents a developmentally challenging problem, requiring intricate regulation of top-bottom (adaxial-abaxial) polarity.

Collective cell migration is an important process during biological development and tissue repair but may turn malignant during tumor …

Introduction This model combines simple Notch signaling with the cellular Potts model (CPM), which drives cell sorting as a result of differential adhesion. Model details are contained in the reference Mulberry and Keshet, 2020.