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Published Models
Models
Published Models
Zebrafish
Guidance by Followers
Morpheus Model ID:
M0006
The migration of zebrafish polster cells is oriented by the migration of follower cells, allowing robust long-range coordination of different cell populations. Introduction Collective cell migration is an important process during biological development and tissue repair.
A. Boutillon
,
S. Escot
,
A. Elouin
,
D. Jahn
,
S. González-Tirado
,
J. Starruß
,
L. Brusch
,
N. B. David
(Authors)
D. Jahn
(Contributor)
DOI:10.1016/j.devcel.2022.05.001
Models
Published Models
Zebrafish
Robust Guidance by Followers
Morpheus Model ID:
M0008
Guidance-by-followers combined with one of several simple rule sets for integration of signals from multiple neighbors provides a robust mechanism for collective cell migration. Introduction Collective cell migration is an important process during biological development and tissue repair but may turn malignant during tumor invasion.
R. Müller
,
A. Boutillon
,
D. Jahn
,
J. Starruß
,
N. B. David
,
L. Brusch
(Authors)
D. Jahn
(Contributor)
DOI:10.3389/fams.2023.1163583
Models
Published Models
Worm
Caenorhabditis elegans L1 Aggregation
Morpheus Model ID:
M7683
Introduction Larvae of the nematode Caenorhabditis elegans aggregate into clusters of several hundred moving individuals when starved during their first larval stage (see video below). Avery et al. proposed that starved larvae produce and respond chemotactically to two diffusible chemical signals, a short-range attractant and a longer range repellent.
L. Avery
,
B. Ingalls
,
C. Dumur
,
A. Artyukhin
(Authors)
L. Brusch
(Contributor)
DOI:10.1371/journal.pcbi.1009231
Models
Published Models
Cell Culture
Collective Motion of MDA-MB-231 Breast Cancer Cells
Morpheus Model ID:
M7678
Introduction Collective motion of human breast cancer cells of the cell line MDA-MB-231 was studied by Lee et al. for individual crawling cells, cell doublets, cell quadruplets and for confluent populations on a two-dimensional substrate.
H. G. Lee
,
K. J. Lee
(Authors)
L. Brusch
(Contributor)
DOI:10.1371/journal.pcbi.1009447
Models
Published Models
Cell Culture
Viral dynamics in monkey and bat cell lines
Morpheus Model ID:
M7677
Introduction Brook et al. studied the effect of distinct immune phenotypes on cellular-scale viral propagation in three mammalian kidney cell lines with different interferon pathways (IFN). Differences in the IFN response upon pathogen invasion allowed to experimentally observe, model and numerically simulate viral dynamics in cells with
C. E. Brook
,
M. Boots
,
K. Chandran
,
A. P. Dobson
,
C. Drosten
,
A. L. Graham
,
B. T. Grenfell
,
M. A. Müller
,
M. Ng
,
L.-F. Wang
,
A. van Leeuwen
(Authors)
C. Munegowda
,
M. Japakhova
,
S. Singhal
,
J. Bürger
,
C. E. Brook
,
L. Brusch
(Contributors)
DOI:10.7554/eLife.48401
Models
Published Models
Cell Culture
Tumor Growth: Unlimited Oxygen and Glucose Supply
Morpheus Model ID:
M0007
Introduction In Jagiella et al. 2017 a quantitative single cell-based mathematical model for multi-cellular tumor spheroids was parametrized by Bayesian inference for different scenarios of nutrition and oxygen supply. The simulations generate of the order of a million individual cells.
N. Jagiella
,
D. Rickert
,
F. J. Theis
,
J. Hasenauer
(Authors)
R. Müller
,
L. Brusch
,
E. Alamoudi
,
J. Hasenauer
(Contributors)
DOI:10.1016/j.cels.2016.12.002
Models
Published Models
Cell Culture
MDCK EMT A
Morpheus Model ID:
M7121
Multiscale simulation of EMT by minimal signaling circuit Introduction We model epithelial-mesenchymal transition (EMT) by first assembling an ODE model for intracellular Yes-associated protein (YAP) signalling and then embedding this single cell model within individual cells in a multiscale simulation.
N. Mukhtar
,
E. N. Cytrynbaum
,
L. Edelstein-Keshet
(Authors)
E. N. Cytrynbaum
,
Y. Xiao
(Contributors)
DOI:10.1016/j.bpj.2022.04.010
Models
Published Models
Cell Culture
MDCK EMT B
Morpheus Model ID:
M7122
Simulated sheet morphology for YAP knockdown (KD) and overexpression (OE) Introduction We model epithelial-mesenchymal transition (EMT) by first assembling an ODE model for intracellular Yes-associated protein (YAP) signalling and then embedding this single cell model within individual cells in a multiscale simulation.
N. Mukhtar
,
E. N. Cytrynbaum
,
L. Edelstein-Keshet
(Authors)
E. N. Cytrynbaum
,
Y. Xiao
(Contributors)
DOI:10.1016/j.bpj.2022.04.010
Models
Published Models
Cell Culture
MDCK EMT C
Morpheus Model ID:
M7123
Multiple models in epithelial-mesenchymal transitions (EMT) Introduction We model epithelial-mesenchymal transition (EMT) by first assembling an ODE model for intracellular Yes-associated protein (YAP) signalling and then embedding this single cell model within individual cells in a multiscale simulation.
N. Mukhtar
,
E. N. Cytrynbaum
,
L. Edelstein-Keshet
(Authors)
E. N. Cytrynbaum
,
Y. Xiao
(Contributors)
DOI:10.1016/j.bpj.2022.04.010
Models
Published Models
Cell Culture
MDCK EMT D
Morpheus Model ID:
M7124
Multiscale model of epithelial-mesenchymal transition (EMT) with intracellular TGFβ signaling circuit Introduction The growth factor TGFβ regulates the snail-zeb intracellular circuit that affects EMT by controlling the levels of E and N-cadherin expression.
N. Mukhtar
,
E. N. Cytrynbaum
,
L. Edelstein-Keshet
(Authors)
E. N. Cytrynbaum
,
Y. Xiao
(Contributors)
DOI:10.1016/j.bpj.2022.04.010
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