Multiscale Models

Introduction This example models a cellular Potts model for autocrine chemotaxis by coupling a CPM to a diffusive chemoattractant. Cell cluster due to chemotaxis towards self-produced chemoattractant. Description It exemplifies the combination of a CPM with a PDE through the chemotaxis towards a diffusive chemoattractant produced by cells.

Introduction This example shows a model of vascular network formation by paracrine signaling (Köhn-Luque et al., 2011) and employs a coupled CPM and reaction-diffusion model. Cells organize into networks due to matrix-anchorage of chemoattractant.

ODE model of the Xenopus oocyte cell cycle coupled to 2D shaped CPM cells that perform divide based on component concentrations Introduction This multiscale model example shows how to define a coupled system of continuous ODEs in discrete CPM cells, how to specify and change time scales between these model formalisms.

Introduction This model show chemotactic aggregation of Dictyostelium. It was constructed by students attending the ECMI modeling week 2012 in Dresden. Aggregation of amoebas through chemotaxis towards waves of cAMP.

Introduction This model of cell polarity shows the coupling of three model formalisms: A cellular Potts model with DirectedMotion that responds to cell polarity (but not directly to the external signal gradient), a co-moving PDE model on the membrane of the cell (to let cell polarity emerge from distributed receptor-signal interactions) and an external signal gradient (implemented as a global field with random fluctuations).

Introduction This model combines simple Notch signaling with the cellular Potts model (CPM), which drives cell sorting as a result of differential adhesion. Model details are contained in the reference Mulberry and Keshet, 2020.

Introduction This model combines simple Notch signaling with the cellular Potts model (CPM), which drives cell sorting as a result of differential adhesion. Model details are contained in the reference Mulberry and Keshet, 2020.

Introduction This model combines simple Notch signaling with the cellular Potts model (CPM), which drives cell sorting as a result of differential adhesion. Model details are contained in the reference Mulberry and Keshet, 2020.

Recent synthetic biology experiments reveal that signaling modules designed to target cell-cell adhesion enable self-organization of …