Mechanistic Model

NHR Conference '25
Taking place in Göttingen in collaboration with NHR@Göttingen, the 3rd NHR Conference brings together high performance computing users …
Mon, 22 Sep 2025 10:00 +0200 — Thu, 25 Sep 2025 14:30 +0200 Aula am Waldweg, Göttingen, Germany
NHR Conference '25
Detoxification and Liver Injury from Acetaminophen (APAP)
Morpheus Model ID: M9496
This multiscale mechanistic liver lobule model is composed of various interacting cell types, such as hepatocytes, residential Kupffer cells and macrophages. It captures hepatocellular acetaminophen (APAP) metabolism, DNA damage response activation, necrotic cell death, macrophage recruitment and the regulation of hepatocellular senescence and proliferation, with qualitatively different outcomes as a function of the initial APAP concentration in blood plasma.
L. Brusch (Contributor)
DOI:10.1038/s41540-022-00238-5
Detoxification and Liver Injury from Acetaminophen (APAP)
Unraveling the effect of intra- and intercellular processes on acetaminophen-induced liver injury
In high dosages, acetaminophen (APAP) can cause severe liver damage, but susceptibility to liver failure varies across individuals and …
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Unraveling the effect of intra- and intercellular processes on acetaminophen-induced liver injury
Tumor Growth: Unlimited Oxygen and Glucose Supply
Morpheus Model ID: M0007
Introduction In Jagiella et al. 2017 a quantitative single cell-based mathematical model for multi-cellular tumor spheroids was parametrized by Bayesian inference for different scenarios of nutrition and oxygen supply. The simulations generate of the order of a million individual cells.
DOI:10.1016/j.cels.2016.12.002
Tumor Growth: Unlimited Oxygen and Glucose Supply