Liver

How does the architectural heterogeneity of the liver with its array of peri-central zones lead to the metabolic zonation across the liver lobule? Introduction Liver micro-architecture is set by an array of central veins interspersed with portal triads.

Hepatocyte–sinusoid alignment (HSA) causes asymmetric shapes in early hepatocellular tumors. Introduction The mammalian liver is subdivided into lobes and further into thousands of hexagonal columns, called lobules, which act in parallel.

Hepatocyte–sinusoid alignment (HSA) supports the coordination of hepatocytes during liver regeneration after damage by carbon tetrachloride. Introduction The regenerative capacity of the mammalian liver did already inspire the fate of Prometheus in Greek Myth but it still poses many questions today that call for spatio-temporal multicellular modeling.

LiSyM-Cancer is a multidisciplinary research network for systems medicine with the focus on liver cancer, its development from …

This multiscale mechanistic liver lobule model is composed of various interacting cell types, such as hepatocytes, residential Kupffer cells and macrophages. It captures hepatocellular acetaminophen (APAP) metabolism, DNA damage response activation, necrotic cell death, macrophage recruitment and the regulation of hepatocellular senescence and proliferation, with qualitatively different outcomes as a function of the initial APAP concentration in blood plasma.

In high dosages, acetaminophen (APAP) can cause severe liver damage, but susceptibility to liver failure varies across individuals and …

Diffusion in Liver Lobule Introduction This model considers diffusion of a marker with concentration $c(x,y,t)$ across a liver lobule. The lobule is patterned into a central zone around the central vein (center of simulation domain) and portal zones around (here six) portal triads that here act as sinks ($c = 0$).

Bile Pressure Drives YAP Signaling During Liver Regeneration Introduction During development and regeneration, tissues must grow to the proper size. But tissue growth is just the result of independent cell cycle control systems in the individual cells.