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Intracellular Signaling
Models
Published Models
Cell Culture
MDCK EMT A
Morpheus Model ID:
M7121
Multiscale simulation of EMT by minimal signaling circuit Introduction We model epithelial-mesenchymal transition (EMT) by first assembling an ODE model for intracellular Yes-associated protein (YAP) signalling and then embedding this single cell model within individual cells in a multiscale simulation.
N. Mukhtar
,
E. N. Cytrynbaum
,
L. Edelstein-Keshet
(Authors)
E. N. Cytrynbaum
,
Y. Xiao
(Contributors)
DOI:10.1016/j.bpj.2022.04.010
Models
Published Models
Cell Culture
MDCK EMT B
Morpheus Model ID:
M7122
Simulated sheet morphology for YAP knockdown (KD) and overexpression (OE) Introduction We model epithelial-mesenchymal transition (EMT) by first assembling an ODE model for intracellular Yes-associated protein (YAP) signalling and then embedding this single cell model within individual cells in a multiscale simulation.
N. Mukhtar
,
E. N. Cytrynbaum
,
L. Edelstein-Keshet
(Authors)
E. N. Cytrynbaum
,
Y. Xiao
(Contributors)
DOI:10.1016/j.bpj.2022.04.010
Models
Published Models
Cell Culture
MDCK EMT C
Morpheus Model ID:
M7123
Multiple models in epithelial-mesenchymal transitions (EMT) Introduction We model epithelial-mesenchymal transition (EMT) by first assembling an ODE model for intracellular Yes-associated protein (YAP) signalling and then embedding this single cell model within individual cells in a multiscale simulation.
N. Mukhtar
,
E. N. Cytrynbaum
,
L. Edelstein-Keshet
(Authors)
E. N. Cytrynbaum
,
Y. Xiao
(Contributors)
DOI:10.1016/j.bpj.2022.04.010
Models
Published Models
Cell Culture
MDCK EMT D
Morpheus Model ID:
M7124
Multiscale model of epithelial-mesenchymal transition (EMT) with intracellular TGFβ signaling circuit Introduction The growth factor TGFβ regulates the snail-zeb intracellular circuit that affects EMT by controlling the levels of E and N-cadherin expression.
N. Mukhtar
,
E. N. Cytrynbaum
,
L. Edelstein-Keshet
(Authors)
E. N. Cytrynbaum
,
Y. Xiao
(Contributors)
DOI:10.1016/j.bpj.2022.04.010
Models
Published Models
Principles
Single Genotype Circuit
Morpheus Model ID:
M2053
Introduction This model combines simple Notch signaling with the cellular Potts model (CPM), which drives cell sorting as a result of differential adhesion. Model details are contained in the reference Mulberry and Keshet, 2020.
N. Mulberry
,
L. Edelstein-Keshet
(Authors)
N. Mulberry
(Contributor)
DOI:10.1088/1478-3975/abb2dc
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