Intracellular Signaling

Multiscale simulation of EMT by minimal signaling circuit Introduction We model epithelial-mesenchymal transition (EMT) by first assembling an ODE model for intracellular Yes-associated protein (YAP) signalling and then embedding this single cell model within individual cells in a multiscale simulation.

Simulated sheet morphology for YAP knockdown (KD) and overexpression (OE) Introduction We model epithelial-mesenchymal transition (EMT) by first assembling an ODE model for intracellular Yes-associated protein (YAP) signalling and then embedding this single cell model within individual cells in a multiscale simulation.

Multiple models in epithelial-mesenchymal transitions (EMT) Introduction We model epithelial-mesenchymal transition (EMT) by first assembling an ODE model for intracellular Yes-associated protein (YAP) signalling and then embedding this single cell model within individual cells in a multiscale simulation.

Multiscale model of epithelial-mesenchymal transition (EMT) with intracellular TGFβ signaling circuit Introduction The growth factor TGFβ regulates the snail-zeb intracellular circuit that affects EMT by controlling the levels of E and N-cadherin expression.

Introduction This model combines simple Notch signaling with the cellular Potts model (CPM), which drives cell sorting as a result of differential adhesion. Model details are contained in the reference Mulberry and Keshet, 2020.