GTPase

ODEs for GTPase interacting with F-actin Introduction Here, we explore the time behavior of a well-mixed GTPase model with negative feedback from F-actin to the GTPase. Description We assume that GTPase ($G$) leads to actin assembly, and that F-actin, denoted by the variable ($F$), leads to GTPase inactivation:

Spatial distribution of GTPase activity Introduction The actin cytoskeleton is regulated by a set of proteins called Small GTPases. The spatial distribution of GTPase activity changes on a timescale of seconds in rapidly moving cells like white blood cells (neutrophils).

Simulated sheet morphology for YAP knockdown (KD) and overexpression (OE) Introduction We model epithelial-mesenchymal transition (EMT) by first assembling an ODE model for intracellular Yes-associated protein (YAP) signalling and then embedding this single cell model within individual cells in a multiscale simulation.

Multiple models in epithelial-mesenchymal transitions (EMT) Introduction We model epithelial-mesenchymal transition (EMT) by first assembling an ODE model for intracellular Yes-associated protein (YAP) signalling and then embedding this single cell model within individual cells in a multiscale simulation.

Multiscale model of epithelial-mesenchymal transition (EMT) with intracellular TGFβ signaling circuit Introduction The growth factor TGFβ regulates the snail-zeb intracellular circuit that affects EMT by controlling the levels of E and N-cadherin expression.

Introduction This paper describes the regimes of behaviour of a 1D spatial (PDE) model for the mutually antagonistic Rac-Rho GTPases, with feedback to and from the extracellular matrix (ECM). Description The Rac-Rho submodels are bistable, and ECM enhances Rho activation.

Introduction This paper describes the regimes of behaviour of a 1D spatial (PDE) model for the mutually antagonistic Rac-Rho GTPases, with feedback to and from the extracellular matrix (ECM). Description The Rac-Rho submodels are bistable, and ECM enhances Rho activation.

Introduction This paper describes the regimes of behaviour of a 1D spatial (PDE) model for the mutually antagonistic Rac-Rho GTPases, with feedback to and from the extracellular matrix (ECM). Description The Rac-Rho submodels are bistable, and ECM enhances Rho activation.