Gnuplotter

1D PDE Barkley Model

Derived from the seminal Hodgkin-Huxley and FitzHugh-Nagumo models, the Barkley model is probably the simplest continuous model for excitable media. It replaces the cubic term in the FitzHugh-Nagumo model with a piece-wise linear term as a simplification that enables fast simulation.

Try the Examples

Examples Menu To explore the potential and modeling features, it is the best to learn by example. Morpheus comes with a range of fully functional example models showcasing a number of model formalism and modeling features.

Step-by-Step Example

To show SBML support in Morpheus as of version 2.1 in practice, we give a step-by-step example of how to download, import and extend an SBML model. 1. Get an SBML Model from BioModels First, we browse the BioModels model repository and select a model.

Convert to 3D

Now we finally arrive at the 3D model. As an example, we further develop the coupled PDE and CPM model with mechanical interaction. Similar to the 1D to 2D case, it is straighforward to extend the dimensionality to 3D.

Coupled ODE Lattice: Lateral Signaling

Morpheus Model ID: M0004 Open in Morpheus History Persistent Identifier Use this permanent link to cite or share this Morpheus model: Copy Introduction This example model cell fate decisions during early patterning of the pancreas (de Back et al.

ODEs in CPM Cells: Cell Cycle and Proliferation

Morpheus Model ID: M0033 Open in Morpheus History Persistent Identifier Use this permanent link to cite or share this Morpheus model: Copy ODE model of the Xenopus oocyte cell cycle coupled to 2D shaped CPM cells that perform divide based on component concentrations

Morpheus 2.2 Release Notes

New GUI functionalities, better performance with OpenMP parallelization of Mappers and Reporters, improved online courses and much more