Cross Section

How does the architectural heterogeneity of the liver with its array of peri-central zones lead to the metabolic zonation across the liver lobule? Introduction Liver micro-architecture is set by an array of central veins interspersed with portal triads.

Hepatocyte–sinusoid alignment (HSA) causes asymmetric shapes in early hepatocellular tumors. Introduction The mammalian liver is subdivided into lobes and further into thousands of hexagonal columns, called lobules, which act in parallel.

Hepatocyte–sinusoid alignment (HSA) supports the coordination of hepatocytes during liver regeneration after damage by carbon tetrachloride. Introduction The regenerative capacity of the mammalian liver did already inspire the fate of Prometheus in Greek Myth but it still poses many questions today that call for spatio-temporal multicellular modeling.