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CPM
Models
Published Models
Cell Culture
Human ESC Colony Patterning
Morpheus Model ID:
M7675
Introduction The formation and maintenance of three germ layers in colonies of human embryonic stem cells (ESCs) is sensitive to the geometry of the colony. In vitro experiments with micropatterns controlling colony shape have previously addressed the underlying spatio-temporal patterning in Warmflash et al.
H. Fooladi
,
P. Moradi
,
A. Sharifi-Zarchi and B. Hosein Khalaj
(Authors)
H. Fooladi
,
L. Brusch
(Contributors)
DOI:10.1093/bioinformatics/btz201
Models
Published Models
Zebrafish
Neural Stem Cell Redivisions in Adult Zebrafish Telencephalon
Morpheus Model ID:
M2984
Introduction Whether individual stem cell divisions are coordinated or random is important for tissue morphogenesis, homeostasis and tumour growth. Lupperger et al. have analyzed the spatio-temporal division patterns of adult neural stem cells (NSC) in the zebrafish telencephalon.
V. Lupperger
,
C. Marr
,
P. Chapouton
(Authors)
V. Lupperger
,
L. Brusch
(Contributors)
DOI:10.1371/journal.pbio.3000708
Models
Published Models
Cell Culture
Human iPSC CDH1-KD : Wildtype Colony Patterning
Morpheus Model ID:
M7672
Introduction Human induced pluripotent stem cells (hiPSCs) can be grown in cell culture where they self-organize spatial patterns. Libby et al. have employed inducible CRISPR interference-driven genetic perturbations to modulate mechanical cell properties like cell-cell adhesion and cortical tension.
A. R. G. Libby
,
D. Briers
,
I. Haghighi
,
D. A. Joy
,
B. R. Conklin
,
C. Belta
,
T. C. McDevitt
(Authors)
L. Brusch
(Contributor)
DOI:10.1016/j.cels.2019.10.008
Models
Published Models
Cell Culture
Human iPSC ROCK1-KD : Wildtype Colony Patterning
Morpheus Model ID:
M7673
Introduction Human induced pluripotent stem cells (hiPSCs) can be grown in cell culture where they self-organize spatial patterns. Libby et al. have employed inducible CRISPR interference-driven genetic perturbations to modulate mechanical cell properties like cell-cell adhesion and cortical tension.
A. R. G. Libby
,
D. Briers
,
I. Haghighi
,
D. A. Joy
,
B. R. Conklin
,
C. Belta
,
T. C. McDevitt
(Authors)
L. Brusch
(Contributor)
DOI:10.1016/j.cels.2019.10.008
Models
Published Models
Cell Culture
Human iPSC Wildtype Colony Growth
Morpheus Model ID:
M7671
Introduction Human induced pluripotent stem cells (hiPSCs) can be grown in cell culture where they self-organize spatial patterns. Libby et al. have employed inducible CRISPR interference-driven genetic perturbations to modulate mechanical cell properties like cell-cell adhesion and cortical tension.
A. R. G. Libby
,
D. Briers
,
I. Haghighi
,
D. A. Joy
,
B. R. Conklin
,
C. Belta
,
T. C. McDevitt
(Authors)
L. Brusch
(Contributor)
DOI:10.1016/j.cels.2019.10.008
Models
Published Models
Principles
Two Layer Circuit
Morpheus Model ID:
M2051
Introduction This model combines simple Notch signaling with the cellular Potts model (CPM), which drives cell sorting as a result of differential adhesion. Model details are contained in the reference Mulberry and Keshet, 2020.
N. Mulberry
,
L. Edelstein-Keshet
(Authors)
N. Mulberry
(Contributor)
DOI:10.1088/1478-3975/abb2dc
Models
Published Models
Principles
Three Layer Circuit
Morpheus Model ID:
M2052
Introduction This model combines simple Notch signaling with the cellular Potts model (CPM), which drives cell sorting as a result of differential adhesion. Model details are contained in the reference Mulberry and Keshet, 2020.
N. Mulberry
,
L. Edelstein-Keshet
(Authors)
N. Mulberry
(Contributor)
DOI:10.1088/1478-3975/abb2dc
Models
Published Models
Principles
Single Genotype Circuit
Morpheus Model ID:
M2053
Introduction This model combines simple Notch signaling with the cellular Potts model (CPM), which drives cell sorting as a result of differential adhesion. Model details are contained in the reference Mulberry and Keshet, 2020.
N. Mulberry
,
L. Edelstein-Keshet
(Authors)
N. Mulberry
(Contributor)
DOI:10.1088/1478-3975/abb2dc
Models
Contributed Examples
CPM
Correlated Random Walkers
Morpheus Model ID:
M2000
Particles moving left and right (as well as up) to mimic actin filament barbed ends Introduction Particles are moving left and right (as well as up) to mimic actin filament barbed ends as motivated by the referenced paper.
L. Edelstein-Keshet
(Author)
D. Jahn
(Contributor)
L. Edelstein-Keshet: Mathematical Models in Cell Biology
Selected Publications
Reoccurring neural stem cell divisions in the adult zebrafish telencephalon are sufficient for the emergence of aggregated spatiotemporal patterns
Regulation of quiescence and cell cycle entry is pivotal for the maintenance of stem cell populations. Regulatory mechanisms, however, …
V. Lupperger
,
C. Marr
,
P. Chapouton
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