Cortical Tension

Human iPSC CDH1-KD : Wildtype Colony Patterning
Morpheus Model ID: M7672
Introduction Human induced pluripotent stem cells (hiPSCs) can be grown in cell culture where they self-organize spatial patterns. Libby et al. have employed inducible CRISPR interference-driven genetic perturbations to modulate mechanical cell properties like cell-cell adhesion and cortical tension.
L. Brusch (Contributor)
DOI:10.1016/j.cels.2019.10.008
Human iPSC CDH1-KD : Wildtype Colony Patterning
Human iPSC ROCK1-KD : Wildtype Colony Patterning
Morpheus Model ID: M7673
Introduction Human induced pluripotent stem cells (hiPSCs) can be grown in cell culture where they self-organize spatial patterns. Libby et al. have employed inducible CRISPR interference-driven genetic perturbations to modulate mechanical cell properties like cell-cell adhesion and cortical tension.
L. Brusch (Contributor)
DOI:10.1016/j.cels.2019.10.008
Human iPSC ROCK1-KD : Wildtype Colony Patterning
Human iPSC Wildtype Colony Growth
Morpheus Model ID: M7671
Introduction Human induced pluripotent stem cells (hiPSCs) can be grown in cell culture where they self-organize spatial patterns. Libby et al. have employed inducible CRISPR interference-driven genetic perturbations to modulate mechanical cell properties like cell-cell adhesion and cortical tension.
L. Brusch (Contributor)
DOI:10.1016/j.cels.2019.10.008
Human iPSC Wildtype Colony Growth