Collective Cell Migration

Collective cell migration due to guidance-by-followers is robust to multiple stimuli
Collective cell migration is an important process during biological development and tissue repair but may turn malignant during tumor …
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Collective cell migration due to guidance-by-followers is robust to multiple stimuli
Robust Guidance by Followers
Morpheus Model ID: M0008
Guidance-by-followers combined with one of several simple rule sets for integration of signals from multiple neighbors provides a robust mechanism for collective cell migration. Introduction Collective cell migration is an important process during biological development and tissue repair but may turn malignant during tumor invasion.
D. Jahn (Contributor)
DOI:10.3389/fams.2023.1163583
Robust Guidance by Followers
MDCK EMT D
Morpheus Model ID: M7124
Multiscale model of epithelial-mesenchymal transition (EMT) with intracellular TGFβ signaling circuit Introduction The growth factor TGFβ regulates the snail-zeb intracellular circuit that affects EMT by controlling the levels of E and N-cadherin expression.
E. N. Cytrynbaum, Y. Xiao (Contributors)
DOI:10.1016/j.bpj.2022.04.010
MDCK EMT D