Cellular Potts Model

Human iPSC CDH1-KD : Wildtype Colony Patterning
Morpheus Model ID: M7672
Introduction Human induced pluripotent stem cells (hiPSCs) can be grown in cell culture where they self-organize spatial patterns. Libby et al. have employed inducible CRISPR interference-driven genetic perturbations to modulate mechanical cell properties like cell-cell adhesion and cortical tension.
L. Brusch (Contributor)
DOI:10.1016/j.cels.2019.10.008
Human iPSC CDH1-KD : Wildtype Colony Patterning
Human iPSC ROCK1-KD : Wildtype Colony Patterning
Morpheus Model ID: M7673
Introduction Human induced pluripotent stem cells (hiPSCs) can be grown in cell culture where they self-organize spatial patterns. Libby et al. have employed inducible CRISPR interference-driven genetic perturbations to modulate mechanical cell properties like cell-cell adhesion and cortical tension.
L. Brusch (Contributor)
DOI:10.1016/j.cels.2019.10.008
Human iPSC ROCK1-KD : Wildtype Colony Patterning
Human iPSC Wildtype Colony Growth
Morpheus Model ID: M7671
Introduction Human induced pluripotent stem cells (hiPSCs) can be grown in cell culture where they self-organize spatial patterns. Libby et al. have employed inducible CRISPR interference-driven genetic perturbations to modulate mechanical cell properties like cell-cell adhesion and cortical tension.
L. Brusch (Contributor)
DOI:10.1016/j.cels.2019.10.008
Human iPSC Wildtype Colony Growth
Two Layer Circuit
Morpheus Model ID: M2051
Introduction This model combines simple Notch signaling with the cellular Potts model (CPM), which drives cell sorting as a result of differential adhesion. Model details are contained in the reference Mulberry and Keshet, 2020.
N. Mulberry (Contributor)
DOI:10.1088/1478-3975/abb2dc
Two Layer Circuit
Three Layer Circuit
Morpheus Model ID: M2052
Introduction This model combines simple Notch signaling with the cellular Potts model (CPM), which drives cell sorting as a result of differential adhesion. Model details are contained in the reference Mulberry and Keshet, 2020.
N. Mulberry (Contributor)
DOI:10.1088/1478-3975/abb2dc
Three Layer Circuit
Single Genotype Circuit
Morpheus Model ID: M2053
Introduction This model combines simple Notch signaling with the cellular Potts model (CPM), which drives cell sorting as a result of differential adhesion. Model details are contained in the reference Mulberry and Keshet, 2020.
N. Mulberry (Contributor)
DOI:10.1088/1478-3975/abb2dc
Single Genotype Circuit
Reoccurring neural stem cell divisions in the adult zebrafish telencephalon are sufficient for the emergence of aggregated spatiotemporal patterns
Regulation of quiescence and cell cycle entry is pivotal for the maintenance of stem cell populations. Regulatory mechanisms, however, …
PDF Cite DOI Model
Reoccurring neural stem cell divisions in the adult zebrafish telencephalon are sufficient for the emergence of aggregated spatiotemporal patterns
Self-organized multicellular structures from simple cell signaling: a computational model
Recent synthetic biology experiments reveal that signaling modules designed to target cell-cell adhesion enable self-organization of …
PDF Cite DOI Model
Self-organized multicellular structures from simple cell signaling: a computational model
Heterogeneous, delayed-onset killing by multiple-hitting T cells: Stochastic simulations to assess methods for analysis of imaging data
Although quantitative insights into the killing behaviour of Cytotoxic T Lymphocytes (CTLs) are necessary for the rational design of …
PDF Cite DOI Model
Heterogeneous, delayed-onset killing by multiple-hitting T cells: Stochastic simulations to assess methods for analysis of imaging data
A dynamic cell recruitment process drives growth of the Drosophila wing by overscaling the vestigial expression pattern
Organs mainly attain their size by cell growth and proliferation, but sometimes also grow through recruitment of undifferentiated …
PDF Cite DOI SysBio Group
A dynamic cell recruitment process drives growth of the Drosophila wing by overscaling the vestigial expression pattern