Cellular Potts Model

Introduction Collective motion of human breast cancer cells of the cell line MDA-MB-231 was studied by Lee et al. for individual crawling cells, cell doublets, cell quadruplets and for confluent populations on a two-dimensional substrate.

In high dosages, acetaminophen (APAP) can cause severe liver damage, but susceptibility to liver failure varies across individuals and …

Membrane pattern allows anisotropic release of substance from cell Introduction This example serves to demonstrate a multiscale model of a cell secreting a substance/molecule and propelling away from the secreted substance.

Changing the adhesion parameters CPM/Interaction/Contact value during simulation runtime Introduction This example model demonstrates the use of variable adhesion values in the CPM/Interaction/Contact/HomophilicAdhesion plugin. Please also see the built-in docu at MorpheuML/CPM/Interaction/Contact/HomophilicAdhesion.

Cells' consumption of cytokine concentration Introduction This example serves to demonstrate the implementation of cells consuming a substrate field, e.g. cytokine. Please also see the built-in docu at MorpheuML/Global/Field and Global/System/DiffEqn.

Multiscale simulation of EMT by minimal signaling circuit Introduction We model epithelial-mesenchymal transition (EMT) by first assembling an ODE model for intracellular Yes-associated protein (YAP) signalling and then embedding this single cell model within individual cells in a multiscale simulation.

Simulated sheet morphology for YAP knockdown (KD) and overexpression (OE) Introduction We model epithelial-mesenchymal transition (EMT) by first assembling an ODE model for intracellular Yes-associated protein (YAP) signalling and then embedding this single cell model within individual cells in a multiscale simulation.

Multiple models in epithelial-mesenchymal transitions (EMT) Introduction We model epithelial-mesenchymal transition (EMT) by first assembling an ODE model for intracellular Yes-associated protein (YAP) signalling and then embedding this single cell model within individual cells in a multiscale simulation.

Multiscale model of epithelial-mesenchymal transition (EMT) with intracellular TGFβ signaling circuit Introduction The growth factor TGFβ regulates the snail-zeb intracellular circuit that affects EMT by controlling the levels of E and N-cadherin expression.

Autoregulatory multicellular incoherent feedforward loop (mIFFL) that generates the 7-stripe even-skipped (eve) expression pattern in Drosophila melanogaster embryogenesis Introduction This model demonstrates the influence of maternal effect genes and gap genes on the even-skipped (eve) gene.