Cellular Potts Model

Introduction This model shows the original cellular Potts model (a.k.a. Glazier-Graner model) of cell sorting based on the Steinberg’s differential adhesion hypothesis. Yellow cells engulf the red cells as a result of differential adhesion.

Cell motility simulation with a reaction-diffusion model for actin waves on the cell perimeter Introduction A partial differential equation model for ‘actin waves’ by Holmes et al., 2012 was simplified and investigated by PDE bifurcation analysis in Hughes et al.

Can a CPM cell be held in a defined position and continue its other dynamics? Introduction CPM cells inherently interact with other cells by volume exclusion (steric interaction) and can get pushed out of the way.

How is the right islet size established during zebrafish pancreas development? Introduction Beta cells in the developing pancreas of zebrafish divide rapidly between 5 and 30 days post fertilization (dpf) and additional beta cells are recruited to the islet.

How can a densely packed PSM tissue mechanically split up into a string of separate somites? Introduction Somitogenesis is the defining developmental process of vertebrate species and essential for the segmentation of the main body axis and, among other repetitive structures, the formation of vertebrae.

Hepatocyte–sinusoid alignment (HSA) supports the coordination of hepatocytes during liver regeneration after damage by carbon tetrachloride. Introduction The regenerative capacity of the mammalian liver did already inspire the fate of Prometheus in Greek Myth but it still poses many questions today that call for spatio-temporal multicellular modeling.

Just over 30 years ago, the cellular Potts model (CPM) was introduced to explain experimental observations of spontaneous cell sorting …

Membrane pattern allows anisotropic release of substance into a chemical synapse Introduction Special cell types, like neurons or immune cells, communicate through a chemical synapse. This includes the anisotropic secretion of a substance into the gap between two cells.

Introduction The mass-conserving secretion and uptake of (signaling) molecules by cells can in Morpheus be achieved with Mappers and scaling fluxes by cell.volume. The intracellular amount of signal may trigger a change in a state variable that could downstream change cell behaviors.

This model also requires the separate file Population_M.csv with the list of lattice nodes where cells shall be initialized. Introduction Initializing the spatial configuration of cells is a key step of every simulation and Morpheus offers all the flexibility for this: