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Cellular Potts Model
Models
Built-in Examples
Cellular Potts Models
Differential Adhesion: Cell Sorting in Two Dimensions
Morpheus Model ID:
M0021
Glazier-Graner Model of cell sorting Introduction This model shows the original cellular Potts model (a.k.a. Glazier-Graner model) of cell sorting based on the Steinberg’s differential adhesion hypothesis. Figure 1.
F. Graner
,
J. A. Glazier
(Authors)
W. de Back
,
D. Jahn
(Contributors)
Morpheus at Recent & Upcoming Events
OpenVT Multicellular Modelling Workshop 2025
Diversity in simulation methods poses challenges in reproducibility, modularity, reusability, and integration within multi-scale simulation. This workshop …
Sun, 13 Jul 2025 09:30 -0600 — 17:00 -0600
Lister Centre, University of Alberta, Edmonton, Canada
Models
Published Models
Cell Culture
Neutrophil Reorientation via Local Feedback and PIP3-Driven Delay
Morpheus Model ID:
M2073
How does immune cell polarity respond to changing stimuli? Introduction Neutrophils are fast-moving immune cells that polarize and reorient in response to external signals. Using optogenetic control of PI3K, recent experiments revealed that when a localized light stimulus becomes global, cells reverse their polarity — a behaviour not predicted by classical models.
J. Algorta
,
J.P. Town
,
O.D. Weiner
,
L. Edelstein-Keshet
(Authors)
Models
Published Models
Mouse
Blastocyst Development
Morpheus Model ID:
M9999
How does the single zygote transform into a 128-cell stage? Introduction This project aims to simulate the development of a human embryo from a single zygote cell to the 128-cell stage using a Cellular Potts Model (CPM).
Z. Cang
,
Y. Wang
,
Q. Wang
,
K. W. Y. Cho
,
W. Holmes
,
Q. Nie
(Authors)
J. Algorta
,
L. Edelstein-Keshet
(Contributors)
Morpheus at Recent & Upcoming Events
OpenVT Reproducible Agent-Based Multicellular Model Competition 2025
This competition is designed to promote and support the development of multicellular models which follow
FAIR principles
Specifically, it recognizes recently published …
Fri, 25 Apr 2025
Virtual
Submit Your Model
Models
Published Models
Drosophila
Drosophila Wing Primordium
Morpheus Model ID:
M1703
How does morphogen transport in a growing tissue feed back on tissue growth through morphogen signaling and cell division? Introduction The Drosophila wing primordium is a two-dimensional epithelial tissue that grows in response to the concentration profile of the morphogen Dpp (see Fig.
J. M. Osborne
,
A. G. Fletcher
,
J. M. Pitt-Francis
,
P. K. Maini
,
D. J. Gavaghan
(Authors)
H. J. Wiederanders
,
P. H. Suhrcke
,
P. Rossbach
(Contributors)
Models
Published Models
Microorganisms
Eukaryotic Cell Motility Based on Actin Waves on the Cell Edge
Morpheus Model ID:
M2072
Cell motility simulation with a reaction-diffusion model for actin waves on the cell perimeter Introduction A partial differential equation model for ‘actin waves’ by Holmes et al., 2012 was simplified and investigated by PDE bifurcation analysis in Hughes et al.
J. Algorta
,
A. Fele-Paranj
,
J. M. Hughes
,
L. Edelstein-Keshet
(Authors)
J. Algorta
,
L. Edelstein-Keshet
(Contributors)
DOI:10.1101/cshperspect.a041796
Models
Contributed Examples
CPM
Hold cell in place
Morpheus Model ID:
M5495
Can a CPM cell be held in a defined position and continue its other dynamics? Introduction CPM cells inherently interact with other cells by volume exclusion (steric interaction) and can get pushed out of the way.
J. Starruß
(Author)
L. Brusch
(Contributor)
Models
Published Models
Zebrafish
Beta Cell Turnover in Pancreatic Islet
Morpheus Model ID:
M2986
How is the right islet size established during zebrafish pancreas development? Introduction Beta cells in the developing pancreas of zebrafish divide rapidly between 5 and 30 days post fertilization (dpf) and additional beta cells are recruited to the islet.
M. N. Akhtar
,
A. Hnatiuk
,
L. Delgadillo-Silva
,
S. Geravandi
,
K. Sameith
,
S. Reinhardt
,
K. Bernhardt
,
S. P. Singh
,
K. Maedler
,
L. Brusch
,
N. Ninov
(Authors)
L. Brusch
,
D. Jahn
(Contributors)
Models
Published Models
Chick
A Multi-cell, Multi-scale Model of Vertebrate Segmentation and Somite Formation
Morpheus Model ID:
M6696
How can a densely packed PSM tissue mechanically split up into a string of separate somites? Introduction Somitogenesis is the defining developmental process of vertebrate species and essential for the segmentation of the main body axis and, among other repetitive structures, the formation of vertebrae.
S. D. Hester
,
J. M. Belmonte
,
J. S. Gens
,
S. G. Clendenon
,
J. A. Glazier
(Authors)
J. Buerger
,
L. Brusch
(Contributors)
»
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