Cell Shape

Simulations of four types of cells with different shapes to demonstrate how the combined target volume, surface area, and medium contact interaction determine the shape of the cell Introduction By setting the volume, surface, and length constraints, a CPM simulation can produce a variety of cell shapes.

Multiple models in epithelial-mesenchymal transitions (EMT) Introduction We model epithelial-mesenchymal transition (EMT) by first assembling an ODE model for intracellular Yes-associated protein (YAP) signalling and then embedding this single cell model within individual cells in a multiscale simulation.

Introduction This paper describes the regimes of behaviour of a 1D spatial (PDE) model for the mutually antagonistic Rac-Rho GTPases, with feedback to and from the extracellular matrix (ECM). Description The Rac-Rho submodels are bistable, and ECM enhances Rho activation.

Introduction This paper describes the regimes of behaviour of a 1D spatial (PDE) model for the mutually antagonistic Rac-Rho GTPases, with feedback to and from the extracellular matrix (ECM). Description The Rac-Rho submodels are bistable, and ECM enhances Rho activation.

Introduction This paper describes the regimes of behaviour of a 1D spatial (PDE) model for the mutually antagonistic Rac-Rho GTPases, with feedback to and from the extracellular matrix (ECM). Description The Rac-Rho submodels are bistable, and ECM enhances Rho activation.