Cell Motility

How does immune cell polarity respond to changing stimuli? Introduction Neutrophils are fast-moving immune cells that polarize and reorient in response to external signals. Using optogenetic control of PI3K, recent experiments revealed that when a localized light stimulus becomes global, cells reverse their polarity — a behaviour not predicted by classical models.

Cell motility simulation with a reaction-diffusion model for actin waves on the cell perimeter Introduction A partial differential equation model for ‘actin waves’ by Holmes et al., 2012 was simplified and investigated by PDE bifurcation analysis in Hughes et al.

Spatial relaxation oscillator produces spatial dynamics and spiral waves, simplification of a previous model for actin waves Introduction Motivated by alternative cell motility modes in eukaryotic cells like Dictyostelium discoideum, we consider a simplified version of an intracellular model for an F-actin negative feedback to an (active/inactive) GTPase system.

We survey a combination of classical and recent experimental and modeling developments in eukaryotic cell migration, from the …

Different cell migration patterns may result from different dynamic states like wave pinning (WP), mixed-mode oscillations (MMO) and relaxation oscillations (RO) of the Rho-Rac-paxillin circuit on the cell membrane.

Introduction Collective motion of human breast cancer cells of the cell line MDA-MB-231 was studied by Lee et al. for individual crawling cells, cell doublets, cell quadruplets and for confluent populations on a two-dimensional substrate.