Cell Migration

Guidance by followers ensures long-range coordination of cell migration through α-catenin mechanoperception
Morphogenesis, wound healing, and some cancer metastases depend upon the migration of cell collectives that need to be guided to their …
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Guidance by followers ensures long-range coordination of cell migration through α-catenin mechanoperception
MDCK EMT A
Morpheus Model ID: M7121
Multiscale simulation of EMT by minimal signaling circuit Introduction We model epithelial-mesenchymal transition (EMT) by first assembling an ODE model for intracellular Yes-associated protein (YAP) signalling and then embedding this single cell model within individual cells in a multiscale simulation.
E. N. Cytrynbaum, Y. Xiao (Contributors)
DOI:10.1016/j.bpj.2022.04.010
MDCK EMT A
MDCK EMT B
Morpheus Model ID: M7122
Simulated sheet morphology for YAP knockdown (KD) and overexpression (OE) Introduction We model epithelial-mesenchymal transition (EMT) by first assembling an ODE model for intracellular Yes-associated protein (YAP) signalling and then embedding this single cell model within individual cells in a multiscale simulation.
E. N. Cytrynbaum, Y. Xiao (Contributors)
DOI:10.1016/j.bpj.2022.04.010
MDCK EMT C
Morpheus Model ID: M7123
Multiple models in epithelial-mesenchymal transitions (EMT) Introduction We model epithelial-mesenchymal transition (EMT) by first assembling an ODE model for intracellular Yes-associated protein (YAP) signalling and then embedding this single cell model within individual cells in a multiscale simulation.
E. N. Cytrynbaum, Y. Xiao (Contributors)
DOI:10.1016/j.bpj.2022.04.010
MDCK EMT C
MDCK EMT D
Morpheus Model ID: M7124
Multiscale model of epithelial-mesenchymal transition (EMT) with intracellular TGFβ signaling circuit Introduction The growth factor TGFβ regulates the snail-zeb intracellular circuit that affects EMT by controlling the levels of E and N-cadherin expression.
E. N. Cytrynbaum, Y. Xiao (Contributors)
DOI:10.1016/j.bpj.2022.04.010
MDCK EMT D