Cell Cycle

Step-by-Step Example

To show SBML support in Morpheus as of version 2.1 in practice, we give a step-by-step example of how to download, import and extend an SBML model. 1. Get an SBML Model from BioModels First, we browse the BioModels model repository and select a model.

Example

Let’s go through an example. We’ll construct a model in which an intracellular cell cycle network (ODE) regulates the division of motile cells which (CPM) release a diffusive cytokine (PDE) which, in turn, controls the cell cycle (ODE).

Relative Time Scales

At this point, you may be asking yourself: ‘All nice and well, but how can I control the relative time scales between the various models?’ And I’d respond:

ODEs in CPM Cells: Cell Cycle and Proliferation

Morpheus Model ID: M0033 Open in Morpheus History Persistent Identifier Use this permanent link to cite or share this Morpheus model: Copy ODE model of the Xenopus oocyte cell cycle coupled to 2D shaped CPM cells that perform divide based on component concentrations

Neural Stem Cell Redivisions in Adult Zebrafish Telencephalon

Morpheus Model ID: M2984 Open in Morpheus History Persistent Identifier Use this permanent link to cite or share this Morpheus model: Copy Introduction Whether individual stem cell divisions are coordinated or random is important for tissue morphogenesis, homeostasis and tumour growth.

Reoccurring neural stem cell divisions in the adult zebrafish telencephalon are sufficient for the emergence of aggregated spatiotemporal patterns

Regulation of quiescence and cell cycle entry is pivotal for the maintenance of stem cell populations. Regulatory mechanisms, however, are poorly understood. In particular, it is unclear how the activity of single stem cells is coordinated within the …