To show SBML support in Morpheus as of version 2.1 in practice, we give a step-by-step example of how to download, import and extend an SBML model.
1. Get an SBML Model from BioModels First, we browse the BioModels model repository and select a model.
Let’s go through an example. We’ll construct a model in which an
intracellular cell cycle network (ODE) regulates the division of motile cells which (CPM) release a diffusive cytokine (PDE) which, in turn, controls the cell cycle (ODE).
At this point, you may be asking yourself:
‘All nice and well, but how can I control the relative time scales between the various models?’
And I’d respond:
Morpheus Model ID: M0033 Open in Morpheus History Persistent Identifier Use this permanent link to cite or share this Morpheus model:
Copy ODE model of the Xenopus oocyte cell cycle coupled to 2D shaped CPM cells that perform divide based on component concentrations
Morpheus Model ID: M2984 Open in Morpheus History Persistent Identifier Use this permanent link to cite or share this Morpheus model:
Copy Introduction Whether individual stem cell divisions are coordinated or random is important for tissue morphogenesis, homeostasis and tumour growth.
Regulation of quiescence and cell cycle entry is pivotal for the maintenance of stem cell populations. Regulatory mechanisms, however, are poorly understood. In particular, it is unclear how the activity of single stem cells is coordinated within the …