Adhesion

Examples Menu To explore the potential and modeling features, it is the best to learn by example. Morpheus comes with a range of fully functional example models showcasing a number of model formalism and modeling features.

Converting the model from the previous chapter into a 2D model is trivial in Morpheus. In the Space section, you only need to change the Size of the Lattice to e.

A simplified version of the Morpheus cell sorting example Introduction A simplified version of the Morpheus built-in example of M0021"cell sorting showing the effect of cell-cell and cell-medium contact energies on the tissue configuration.

Example demonstrating how adhesion energies affect cell shape and the cell-cell contact region Introduction We simulate two CPM cells of the same type to demonstrate how adhesion energies affect cell shape and the cell-cell contact region.

This multiscale mechanistic liver lobule model is composed of various interacting cell types, such as hepatocytes, residential Kupffer cells and macrophages. It captures hepatocellular acetaminophen (APAP) metabolism, DNA damage response activation, necrotic cell death, macrophage recruitment and the regulation of hepatocellular senescence and proliferation, with qualitatively different outcomes as a function of the initial APAP concentration in blood plasma.

Introduction Comparison of spatio-temporal model output to experimental measurements or between model variants all require the application of summary statistics. For multicellular models, statistical properties of the cell configuration at given times or across time are of interest and Morpheus provides some Analysis/Trackers for that: CellTracker, DisplacementTracker, ClusteringTracker and ContactLogger.

Introduction Larvae of the nematode Caenorhabditis elegans aggregate into clusters of several hundred moving individuals when starved during their first larval stage (see video below). Avery et al. proposed that starved larvae produce and respond chemotactically to two diffusible chemical signals, a short-range attractant and a longer range repellent.

Introduction Collective motion of human breast cancer cells of the cell line MDA-MB-231 was studied by Lee et al. for individual crawling cells, cell doublets, cell quadruplets and for confluent populations on a two-dimensional substrate.

Changing the adhesion parameters CPM/Interaction/Contact value during simulation runtime Introduction This example model demonstrates the use of variable adhesion values in the CPM/Interaction/Contact/HomophilicAdhesion plugin. Please also see the built-in docu at MorpheuML/CPM/Interaction/Contact/HomophilicAdhesion.

Multiple models in epithelial-mesenchymal transitions (EMT) Introduction We model epithelial-mesenchymal transition (EMT) by first assembling an ODE model for intracellular Yes-associated protein (YAP) signalling and then embedding this single cell model within individual cells in a multiscale simulation.