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A diffusible small-RNA-based Turing system dynamically coordinates organ polarity
The formation of a flat and thin leaf presents a developmentally challenging problem, requiring intricate regulation of adaxial–abaxial …
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A diffusible small-RNA-based Turing system dynamically coordinates organ polarity
Collective cell migration due to guidance-by-followers is robust to multiple stimuli
Collective cell migration is an important process during biological development and tissue repair but may turn malignant during tumor …
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Collective cell migration due to guidance-by-followers is robust to multiple stimuli
Unraveling the effect of intra- and intercellular processes on acetaminophen-induced liver injury
In high dosages, acetaminophen (APAP) can cause severe liver damage, but susceptibility to liver failure varies across individuals and …
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Unraveling the effect of intra- and intercellular processes on acetaminophen-induced liver injury
Guidance by followers ensures long-range coordination of cell migration through α-catenin mechanoperception
Morphogenesis, wound healing, and some cancer metastases depend upon the migration of cell collectives that need to be guided to their …
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Guidance by followers ensures long-range coordination of cell migration through α-catenin mechanoperception
Reoccurring neural stem cell divisions in the adult zebrafish telencephalon are sufficient for the emergence of aggregated spatiotemporal patterns
Regulation of quiescence and cell cycle entry is pivotal for the maintenance of stem cell populations. Regulatory mechanisms, however, …
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Reoccurring neural stem cell divisions in the adult zebrafish telencephalon are sufficient for the emergence of aggregated spatiotemporal patterns
Self-organized multicellular structures from simple cell signaling: a computational model
Recent synthetic biology experiments reveal that signaling modules designed to target cell-cell adhesion enable self-organization of …
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Self-organized multicellular structures from simple cell signaling: a computational model
Heterogeneous, delayed-onset killing by multiple-hitting T cells: Stochastic simulations to assess methods for analysis of imaging data
Although quantitative insights into the killing behaviour of Cytotoxic T Lymphocytes (CTLs) are necessary for the rational design of …
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Heterogeneous, delayed-onset killing by multiple-hitting T cells: Stochastic simulations to assess methods for analysis of imaging data
A dynamic cell recruitment process drives growth of the Drosophila wing by overscaling the vestigial expression pattern
Organs mainly attain their size by cell growth and proliferation, but sometimes also grow through recruitment of undifferentiated …
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A dynamic cell recruitment process drives growth of the Drosophila wing by overscaling the vestigial expression pattern
Dynamic Polarization of the Multiciliated Planarian Epidermis between Body Plan Landmarks
Polarity is a universal design principle of biological systems that manifests at all organizational scales, yet its coordination across …
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Dynamic Polarization of the Multiciliated Planarian Epidermis between Body Plan Landmarks
Experimental and computational analyses reveal that environmental restrictions shape HIV-1 spread in 3D cultures
Pathogens face varying microenvironments in vivo, but suitable experimental systems and analysis tools to dissect how three-dimensional …
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Experimental and computational analyses reveal that environmental restrictions shape HIV-1 spread in 3D cultures