Worm
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Patterned Growth Regulation
Can morphodynamic feedback generate complex body shapes like that of a long and thin flatworm? Introduction During flatworm development and regeneration, morphogens like diffusible Wnt ligands self-organize concentration gradients that contribute to tissue morphogenesis, differentiation and the establishment of the body axes.
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Steady State Growth Regulation
How to stop tissue growth at a specific size? Introduction The growth and regeneration of organisms into complex shapes remains largly an open question. This model page presents the reproduction of a theoretical study of Kaity et al.
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C. elegans Aggregation
Introduction Larvae of the nematode Caenorhabditis elegans aggregate into clusters of several hundred moving individuals when starved during their first larval stage (see video below). Avery et al. proposed that starved larvae produce and respond chemotactically to two diffusible chemical signals, a short-range attractant and a longer range repellent.
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Planarian Regeneration (Double Head)
Spatio-temporal model of planar polarity regulation during planarian regeneration Introduction This simulation reproduces Figure 4D of the referenced paper. Parameter values correspond to the β-catenin-1(RNAi) pattern as given in Table S2 of the referenced paper.
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Planarian Regeneration (Wild Type)
Spatio-temporal model of planar polarity regulation during planarian regeneration Introduction This simulation reproduces Figure 4C of the referenced paper. Parameter values correspond to the wild type pattern (control) as given in Table S2 of the referenced paper.