Principles
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Chemotaxis Model Checking
Introduction Comparison of spatio-temporal model output to experimental measurements or between model variants all require the application of summary statistics. For multicellular models, statistical properties of the cell configuration at given times or across time are of interest and Morpheus provides some Analysis/Trackers for that: CellTracker, DisplacementTracker, ClusteringTracker and ContactLogger.
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Cell Polarity & Migration (MMO)
Different cell migration patterns may result from different dynamic states like wave pinning (WP), mixed-mode oscillations (MMO) and relaxation oscillations (RO) of the Rho-Rac-paxillin circuit on the cell membrane.
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Cell Polarity & Migration 1 (Generic)
Introduction This paper describes the regimes of behaviour of a 1D spatial (PDE) model for the mutually antagonistic Rac-Rho GTPases, with feedback to and from the extracellular matrix (ECM). Description The Rac-Rho submodels are bistable, and ECM enhances Rho activation.
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Cell Polarity & Migration 2 (Slip)
Introduction This paper describes the regimes of behaviour of a 1D spatial (PDE) model for the mutually antagonistic Rac-Rho GTPases, with feedback to and from the extracellular matrix (ECM). Description The Rac-Rho submodels are bistable, and ECM enhances Rho activation.
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Cell Polarity & Migration 3 (Catch-Slip)
Introduction This paper describes the regimes of behaviour of a 1D spatial (PDE) model for the mutually antagonistic Rac-Rho GTPases, with feedback to and from the extracellular matrix (ECM). Description The Rac-Rho submodels are bistable, and ECM enhances Rho activation.
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Morphodynamics 1
Introduction This model combines simple Notch signaling with the cellular Potts model (CPM), which drives cell sorting as a result of differential adhesion. Model details are contained in the reference Mulberry and Keshet, 2020.
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Morphodynamics 2
Introduction This model combines simple Notch signaling with the cellular Potts model (CPM), which drives cell sorting as a result of differential adhesion. Model details are contained in the reference Mulberry and Keshet, 2020.
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Morphodynamics 3
Introduction This model combines simple Notch signaling with the cellular Potts model (CPM), which drives cell sorting as a result of differential adhesion. Model details are contained in the reference Mulberry and Keshet, 2020.