Mouse
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Liver Zonation
How does the architectural heterogeneity of the liver with its array of peri-central zones lead to the metabolic zonation across the liver lobule? Introduction Liver micro-architecture is set by an array of central veins interspersed with portal triads.
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Blastocyst Development
How does the single zygote transform into a 128-cell stage? Introduction This project aims to simulate the development of a human embryo from a single zygote cell to the 128-cell stage using a Cellular Potts Model (CPM).
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Hepatocellular Carcinoma
Hepatocyte–sinusoid alignment (HSA) causes asymmetric shapes in early hepatocellular tumors. Introduction The mammalian liver is subdivided into lobes and further into thousands of hexagonal columns, called lobules, which act in parallel.
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Liver Regeneration from CCl4
Hepatocyte–sinusoid alignment (HSA) supports the coordination of hepatocytes during liver regeneration after damage by carbon tetrachloride. Introduction The regenerative capacity of the mammalian liver did already inspire the fate of Prometheus in Greek Myth but it still poses many questions today that call for spatio-temporal multicellular modeling.
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Tissue Size Control
Bile Pressure Drives YAP Signaling During Liver Regeneration Introduction During development and regeneration, tissues must grow to the proper size. But tissue growth is just the result of independent cell cycle control systems in the individual cells.