Proliferation in Two Dimensions

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This model shows a simulation of a growing cell population, using the cellular Potts model.

Growing cell population.
Growing cell population.


The model specifies CellType which has a VolumeConstraint and a Proliferation plugin.

In the Proliferation plugin, the ‘Conditions for a cell to divide are given. Here, each cell that has more than 90% of the target volume has a small probability to divide. Once a division has taken place, the Equation defined in the Triggers elements are triggered.


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<?xml version='1.0' encoding='UTF-8'?>
<MorpheusModel version="3">
        <Variable symbol="c" value="0.0"/>
        <Lattice class="hexagonal">
            <Size symbol="size" value="500 500 0"/>
                <Condition boundary="x" type="periodic"/>
                <Condition boundary="y" type="periodic"/>
        <SpaceSymbol symbol="space"/>
        <StartTime value="0"/>
        <StopTime symbol="stoptime" value="4e4"/>
        <TimeSymbol symbol="time"/>
        <CellType class="biological" name="cells">
            <Property symbol="p" value="5e-5" name="proliferation rate"/>
            <Property symbol="d" value="0" name="divisions"/>
            <Property symbol="c" value="0" name="color"/>
            <VolumeConstraint target="500" strength="1"/>
            <SurfaceConstraint target="0.9" mode="aspherity" strength="1"/>
            <System solver="euler" time-step="1.0">
                <Rule symbol-ref="c">
                    <Expression>if( c > 0, c-1, 0)</Expression>
            <CellDivision division-plane="random">
                <Condition>rand_uni(0,1) &lt; p</Condition>
                    <Rule symbol-ref="d">
                    <Rule symbol-ref="c" name="color after division">
        <Interaction default="0">
            <Contact type1="cells" type2="cells" value="-4"/>
        <MonteCarloSampler stepper="edgelist">
            <MCSDuration value="1.0"/>
            <MetropolisKinetics temperature="3" yield="0.1"/>
        <ShapeSurface scaling="norm">
        <Population size="1" type="cells">
            <InitCircle mode="regular" number-of-cells="20">
                <Dimensions radius="35" center="250, 250, 0"/>
        <Gnuplotter time-step="1000" decorate="false">
            <Terminal name="png"/>
                <Cells value="c" min="0.0" max="1">
                        <Color value="1" color="red"/>
                        <Color value="0.0" color="green"/>
                <CellLabels fontsize="8" value="d"/>
        <Logger time-step="100">
                <Symbol symbol-ref="celltype.cells.size"/>
                <Plot log-commands="true" time-step="10000">
                    <Style point-size="0.5" grid="true" style="linespoints"/>
                    <Terminal terminal="png"/>
                    <X-axis minimum="0" maximum="stoptime">
                        <Symbol symbol-ref="time"/>
                    <Y-axis minimum="0" maximum="100">
                        <Symbol symbol-ref="celltype.cells.size"/>


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