Full title: Spatial Effects on Killing Kinetics of Cytotoxic T Lymphocytes Date: 08.09.2021 Authors: R. J. Beck, D. I. Bijker, J. B. Beltman Curators: J. B. Beltman, D. Jahn Software: Morpheus (open source). Download from: https://morpheus.gitlab.io Model ID: https://identifiers.org/morpheus/M9495 Units: [time] = s Reference: This model is the original used in the publication, up to technical updates: R. J. Beck, D. I. Bijker, J. B. Beltman: Heterogeneous, delayed-onset killing by multiple-hitting T cells: Stochastic simulations to assess methods for analysis of imaging data. PLoS Comput. Biol. 16 (7): 1-25, 2020. https://doi.org/10.1371/journal.pcbi.1007972

2

is.dead

rand_uni(0,1)<hit.chance*(maturity>=minhit)*(1-is.dead)*ctl.attn hits.received + 1 (hits.received+1)>=nhits ctl.attn>0 maturity+1 ctl.attn==0 0 1 3 2.5