Diffusion Model of Gap Genes in Drosophila melanogasterFull title: The multicellular incoherent feedforward loop motif generates spatial patterns
Date: 16.03.2019
Authors: M. R. Regueira, J. D. García, A. R.-P. Aradas
Contributors: M. R. Regueira
Software: Morpheus (open-source). Download from https://morpheus.gitlab.io
Units: [time] = min, [space] = μm · 0.5
Model ID: https://identifiers.org/morpheus/M6694
Comment: Autoregulatory multicellular incoherent feedforward loop (mIFFL) that generates the 7-stripe even-skipped (eve) expression pattern in Drosophila melanogaster embryogenesis
This model is the original used in the publication, up to technical updates.
Reference: M. R. Regueira, J. D. García, A. R.-P. Aradas: The multicellular incoherent feedforward loop motif generates spatial patterns. bioRxiv, 2019.
https://doi.org/10.1101/579342p_bicoid-deg_bicoid*BICOIDp_nanos-deg_nanos*M_NANOSp_hunchback-deg_hunchback*HUNCHBACKp_caudal-deg_caudal*CAUDALp_giant-deg_giant*GIANTp_kruppel-deg_kruppel*KRUPPELp_knirps-deg_knirps*KNIRPSp_tailless-deg_tailless*TAILLESS p_eve_rep-deg_eve_rep*EVE_REPp_eve_rep_cons-deg_eve_rep_cons*EVE_REP_CONSp_rep_eve_rep_cons-deg_rep_eve_rep_cons*REP_EVE_REP_CONSp_eve-deg_eve*EVE2.5if((con_bicoid>19 or con_hunchback>49 or con_tailless>101) and con_caudal<122 and con_kruppel<139 and con_knirps<4 and con_nanos<110, 31.3, 0)
if((con_nanos>125) and con_hunchback<61, 7.65, 0)if((con_bicoid>9 or con_kruppel>103 or con_caudal>151) and con_hunchback<176.98 and con_giant<4 and con_knirps<115 and con_tailless<20 and time>4, 16.3, 0)if((con_bicoid>40 or con_caudal>133 or con_giant>85) and con_kruppel<15 and con_tailless<102 and time>4, 16.1, 0)if((con_bicoid>5 or con_caudal>152 or con_knirps>94) and con_hunchback<7 and con_kruppel<141 and con_giant<220 and con_tailless<18 and time>4, 17, 0)if(con_hunchback>40 and con_giant<30 and con_kruppel<10 and time>40, 50,
if(con_eve>14, 50, 0)
)if(con_hunchback>40 and con_giant<30 and con_kruppel<10 and time>40, 50,
if(con_eve>14, 50, 0)
)if(con_rep_eve_rep_cons>0.1, 0, 1)if(con_hunchback>40 and con_giant<30 and con_kruppel<10 and con_nanos<105 and time>40, 2,
if(con_eve_rep<0.1 and con_eve_rep_cons<0.1 and con_bicoid<70 and con_nanos<115, 2, 0)
) if(con_eve>1, 1, 0)22.5