Model ID: https://identifiers.org/morpheus/M2074 File type: Supplementary model Software: Morpheus (open source). Download from: https://morpheus.gitlab.io Full title: How Negative Feedback from Filamentous Actin Affects Cell Shapes and Motility Authors: J. M. Hughes, J. Algorta, L. Edelstein-Keshet Submitter: J. Algorta Curator: D. Jahn Date: 07.06.2026 Reference: This model is the original used in the publication, up to technical updates: J. M. Hughes, J. Algorta, L. Edelstein-Keshet: How negative feedback from filamentous actin affects cell shapes and motility. arXiv 2602.08779, 2026. https://doi.org/10.48550/arXiv.2602.08779 Comment: This model simulates the transition from cell turning back to directed cell motion due to a linearly decreasing negative feedback rate s(t), simulated in Morpheus for Figure 13 of the publication. PDE model for F-actin negative feedback to GTPases, and GTPase promotion of F-actin. The reaction-diffusion PDEs are implemented on the cell edge. u = active GTPase (Rac), v = inactive GTPase, F = F-actin.

time 2.0 A -A eps*(p0+p1*u-F) 4*(time_var>150)*(time_var<200)*rand_norm(0,1) s0*(time < 0.25*tf) + (s0-(s0-sf)*(time-0.25*tf)/(0.5*tf))*(time > 0.25*tf)*(time < 0.75*tf) + sf*(time > 0.75*tf) 2 6