Model ID: https://identifiers.org/morpheus/M2073 File type: Supplementary model Software: Morpheus (open source). Download from: https://morpheus.gitlab.io Full title: Neutrophil Reorientation via Local Feedback and PIP3-Driven Delay Authors: J. Algorta, J. P. Town, O. D. Weiner, L. Edelstein-Keshet Submitter: J. Algorta Curator: L. Brusch Date: 15.05.2025 Reference: This model is the original used in the publication, up to technical updates: J. Algorta, J. P. Town, O. D. Weiner, L. Edelstein-Keshet: Investigating local negative feedback of Rac activity by mathematical models and cell-motility simulations. iScience 29 (2): 114641, 2026. https://doi.org/10.1016/j.isci.2026.114641 Comment: This model simulates Rac activation and polarity via wave-pinning under a spatial gradient stimulus (U), which dynamically changes or varies along the y-axis.

time>=200 noisy(0.5) time>=250 noisy((lattice.y-l.y) / lattice.y) max(0,(v+rand_norm(0,noise))) 2.0 F -F

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