Model ID: https://identifiers.org/morpheus/M2071 File type: Supplementary model Software: Morpheus (open source). Download from: https://morpheus.gitlab.io Full title: Simplified Actin Waves in Eukaryotic Cell Motility – Spiral Waves in 2D Authors: J. M. Hughes and L. Edelstein-Keshet Submitter: L. Edelstein-Keshet Curator: D. Jahn Date: 29.10.2024 Reference: J. Algorta, A. Fele-Paranj, J. M. Hughes, L. Edelstein-Keshet: Modeling and Simulating Single and Collective Cell Motility. Cold Spring Harb. Perspect. Biol., 2025. https://doi.org/10.1101/cshperspect.a041796 This model reproduces the model and results obtained with Morpheus in Figure 1 of the original publication. Comment: PDE model for F-actin negative feedback to GTPases, and GTPase promotion of F-actin. u = active GTPases v = inactive GTPase F = F-actin

(b+gamma*u^n)*v- u*(1+s*F+u^2) -(b+gamma*u^n)*v+ u*(1+s*F+u^2) epsilon*(p0+p1*u-F) dx*space.x dx*space.y 1