Full title: Tumor Growth: Unlimited Oxygen and Glucose Supply Date: 21.01.2022 Authors: N. Jagiella, D. Rickert, F. J. Theis, J. Hasenauer Curators: R. Müller, L. Brusch, E. Alamoudi, J. Hasenauer Software: Morpheus (open-source), download from https://morpheus.gitlab.io ModelID: https://identifiers.org/morpheus/M0007 Reference: This model reproduces the published results of scenario I, originally obtained with a different simulator: N. Jagiella, D. Rickert, F. J. Theis, J. Hasenauer: Parallelization and High-Performance Computing Enables Automated Statistical Inference of Multi-scale Models. Cell Systems 4 (2): 194-206.e9, 2017. https://doi.org/10.1016/j.cels.2016.12.002 The model is set up for 2D but in principle ready for 3D as well.

ke_pro*c-ke_deg*e

max(L_init_num_scaling_to_exp,sqrt(V_spheroid/pi))*length_unit (time-t0)/24 To await the initial expansion of point-seeded cells, a transient of 20 time units is subtracted here and hidden via Analysis/Logger/Restriction. e_cell/0.7 prolif*0.6 L_init_num*10

radius.micrometer-sqrt((cell.center.x-com.x)^2+(cell.center.y-com.y)^2)*length_unit 1 rand_uni(0,1) < (exp(-L/L_div_num)*(e_cell>e_div)) rand_uni(0,1) < k_re_max

1 e_cell_inter

if(medium_contact==1,sqrt(cell.volume/pi),LTmp+1.28*sqrt(4*cell.volume/pi)) L*length_unit

1 e_cell_inter m == m_d*(e_cell>-1) 1 rand_uni(0,1) < (exp(-L/L_div_num)*(e_cell>e_div)) prolif == 0 1 1 m+(rand_uni(0,1)<k_div_max*1*m_d)

if(medium_contact==1,sqrt(cell.volume/pi),LTmp+1.28*sqrt(4*cell.volume/pi)) L*length_unit 1 2

export LANG=C; awk -f ./prolif.awk 10 300 1 %time ; awk -f ./ecm.awk 10 300 1 %time export LANG=C; awk -f ./cmp.awk 438