Full title: Guidance by followers ensures long-range coordination of cell migration through α-catenin mechanoperception Date: 20.06.2022 Authors: A. Boutillon, S. Escot, A. Elouin, D. Jahn, S. González-Tirado, J. Starruß, L. Brusch, N. B. David Contributors: D. Jahn Software: Morpheus (open-source). Download from https://morpheus.gitlab.io Time unit: min Model ID: https://identifiers.org/morpheus/M0006 Comment: The migration of zebrafish polster cells is oriented by the migration of follower cells, allowing robust long-range coordination of different cell populations. This model is the original used in the publication, up to technical updates. Reference: A. Boutillon, S. Escot, A. Elouin, D. Jahn, S. González-Tirado, J. Starruß, L. Brusch, N. B. David: Guidance by followers ensures long-range coordination of cell migration through α-catenin mechanoperception. Dev. Cell 57 (12): 1529-1544.e5, 2022. https://doi.org/10.1371/journal.pcbi.1009231
Guidance by Followers 1 Strength of the DirectedMotion plugin Strength of the DirectedMotion plugin Angle between cell movement and direction to the neighbor. Below max_angle, the cell is considered as moving towards the neighbouring cell and will influence its direction Minimal velocity for a cell to influence its neighbors Needed for NeighborhoodReporters neighbor_velocity_x and neighbor_velocity_y Cell colors: - white: uninitialized cells (time >= init_time) - yellow: axial cells (RandT_or_Mech_motion_strength == 0) - green: polster cells (RandT_or_Mech_motion_strength > 0) After init_time, set the properties of axial cells time == init_time and cell.center.y <= 360 directed_motion_strength_global 0 2 Set to strength = 0 for polster cells After init_time, set the properties of polster cells time == init_time and cell.center.y > 360 RandT_or_Mech_motion_strength_global 0 3 (time >= tumble.last + tumble.run_duration) time run_duration_adjustment * rand_gamma(0.5, 5) angle, 0 , 1 Needs time-step = 1 Needs time-step = 1 py_induced_dir_x, py_induced_dir_y, 0.0 if(mech_induced_dir.abs > 0, mech_induced_dir, RaT_dir) RandT or mechanically induced movement. Set to strength = 0 for axial cells 1 3 1