Full title: Guidance by followers ensures long-range coordination of cell migration through α-catenin mechanoperception
Date: 20.06.2022
Authors: A. Boutillon, S. Escot, A. Elouin, D. Jahn, S. González-Tirado, J. Starruß, L. Brusch, N. B. David
Contributors: D. Jahn
Software: Morpheus (open-source). Download from https://morpheus.gitlab.io
Time unit: min
Model ID: https://identifiers.org/morpheus/M0006
Comment: The migration of zebrafish polster cells is oriented by the migration of follower cells, allowing robust long-range coordination of different cell populations.
This model is the original used in the publication, up to technical updates.
Reference: A. Boutillon, S. Escot, A. Elouin, D. Jahn, S. González-Tirado, J. Starruß, L. Brusch, N. B. David: Guidance by followers ensures long-range coordination of cell migration through α-catenin mechanoperception. Dev. Cell 57 (12): 1529-1544.e5, 2022.
https://doi.org/10.1371/journal.pcbi.1009231
Guidance by Followers1Strength of the DirectedMotion pluginStrength of the DirectedMotion pluginAngle between cell movement and direction to the neighbor. Below max_angle, the cell is considered as moving towards the neighbouring cell and will influence its directionMinimal velocity for a cell to influence its neighborsNeeded for NeighborhoodReporters neighbor_velocity_x and neighbor_velocity_yCell colors:
- white: uninitialized cells (time >= init_time)
- yellow: axial cells (RandT_or_Mech_motion_strength == 0)
- green: polster cells (RandT_or_Mech_motion_strength > 0)After init_time, set the properties of axial cellstime == init_time and cell.center.y <= 360directed_motion_strength_global02Set to strength = 0 for polster cellsAfter init_time, set the properties of polster cellstime == init_time and cell.center.y > 360RandT_or_Mech_motion_strength_global03(time >= tumble.last + tumble.run_duration)timerun_duration_adjustment * rand_gamma(0.5, 5)angle, 0 , 1Needs time-step = 1Needs time-step = 1py_induced_dir_x, py_induced_dir_y, 0.0if(mech_induced_dir.abs > 0, mech_induced_dir, RaT_dir)RandT or mechanically induced movement. Set to strength = 0 for axial cells131