The 7th Annual SysMod Meeting will be a forum for discussion about the combined use of systems biology modeling and bioinformatics to understand biology, and disease. The meeting will take place in July 2022, during the International Conference on Intelligent Systems for Molecular Biology (ISMB) 2022. The meeting will feature three keynote talks and contributed presentations. The annual ISMB is the flagship meeting of the International Society for Computational Biology (ISCB). The 2022 conference is the 30th ISMB conference, which has grown to become the world’s largest bioinformatics/computational biology conference. ISMB 2022 will offer both in-person and virtual attendance in Madison, Wisconsin, July 10-14 at Monona Terrace Convention Center or in a virtual interface. ISMB brings together scientists from computer science, molecular biology, mathematics, statistics and related fields. Its principal focus is on the development and application of advanced computational methods for biological problems.