L. Brusch

Introduction This model of cell polarity shows the coupling of three model formalisms: A cellular Potts model with DirectedMotion that responds to cell polarity (but not directly to the external signal gradient), a co-moving PDE model on the membrane of the cell (to let cell polarity emerge from distributed receptor-signal interactions) and an external signal gradient (implemented as a global field with random fluctuations).

Can a CPM cell be held in a defined position and continue its other dynamics? Introduction CPM cells inherently interact with other cells by volume exclusion (steric interaction) and can get pushed out of the way.

How is the right islet size established during zebrafish pancreas development? Introduction Beta cells in the developing pancreas of zebrafish divide rapidly between 5 and 30 days post fertilization (dpf) and additional beta cells are recruited to the islet.

How can a densely packed PSM tissue mechanically split up into a string of separate somites? Introduction Somitogenesis is the defining developmental process of vertebrate species and essential for the segmentation of the main body axis and, among other repetitive structures, the formation of vertebrae.

How to dynamically regulate individual cell proliferation? Introduction Proliferation of individual cells may be coupled through the dependence on common resources. This turns the otherwise exponential growth of the population size into, for example, logistic growth.

Hepatocyte–sinusoid alignment (HSA) causes asymmetric shapes in early hepatocellular tumors. Introduction The mammalian liver is subdivided into lobes and further into thousands of hexagonal columns, called lobules, which act in parallel.

Hepatocyte–sinusoid alignment (HSA) supports the coordination of hepatocytes during liver regeneration after damage by carbon tetrachloride. Introduction The regenerative capacity of the mammalian liver did already inspire the fate of Prometheus in Greek Myth but it still poses many questions today that call for spatio-temporal multicellular modeling.

This example model demonstrates how to obtain consistent results in physical units together with the freedom to choose arbitrary lattice and time discretizations. Introduction Often, one starts to build a model with a particular lattice size and time scaling.

Introduction The mass-conserving secretion and uptake of (signaling) molecules by cells can in Morpheus be achieved with Mappers and scaling fluxes by cell.volume. The intracellular amount of signal may trigger a change in a state variable that could downstream change cell behaviors.

This model also requires the separate file Population_M.csv with the list of lattice nodes where cells shall be initialized. Introduction Initializing the spatial configuration of cells is a key step of every simulation and Morpheus offers all the flexibility for this: