W. de Back

Introduction This example model cell fate decisions during early patterning of the pancreas (de Back et al., 2012). The simple gene regulatory network of each cell is coupled to adjacent cells by lateral (juxtacrine) signaling.

Introduction This example shows a model of vascular network formation by paracrine signaling (Köhn-Luque et al., 2011) and employs a coupled CPM and reaction-diffusion model. Cells organize into networks due to matrix-anchorage of chemoattractant.

The formation of a flat and thin leaf presents a developmentally challenging problem, requiring intricate regulation of adaxial–abaxial …

A diffusible small-RNA-based Turing system dynamically coordinates organ polarity. Introduction The formation of a flat and thin leaf presents a developmentally challenging problem, requiring intricate regulation of top-bottom (adaxial-abaxial) polarity.

Morpheus is a modeling environment for the simulation and integration of cell-based models with ordinary differential equations and reaction-diffusion systems. It allows rapid development of multiscale models in biological terms and mathematical expressions rather than programming code. Its graphical user interface supports the entire workflow from model construction and simulation to visualization, archiving and batch processing.

During embryonic vasculogenesis, endothelial precursor cells of mesodermal origin known as angioblasts assemble into a characteristic …