L. Brusch

Introduction This example model cell fate decisions during early patterning of the pancreas (de Back et al., 2012). The simple gene regulatory network of each cell is coupled to adjacent cells by lateral (juxtacrine) signaling.

How is the right islet size established during zebrafish pancreas development? Introduction Beta cells in the developing pancreas of zebrafish divide rapidly between 5 and 30 days post fertilization (dpf) and additional beta cells are recruited to the islet.

How to dynamically regulate individual cell proliferation? Introduction Proliferation of individual cells may be coupled through the dependence on common resources. This turns the otherwise exponential growth of the population size into, for example, logistic growth.

Collective cell migration is an important process during biological development and tissue repair but may turn malignant during tumor …

The migration of zebrafish polster cells is oriented by the migration of follower cells, allowing robust long-range coordination of different cell populations. Introduction Collective cell migration is an important process during biological development and tissue repair.

Guidance-by-followers combined with one of several simple rule sets for integration of signals from multiple neighbors provides a robust mechanism for collective cell migration. Introduction Collective cell migration is an important process during biological development and tissue repair but may turn malignant during tumor invasion.

Diffusion in Liver Lobule Introduction This model considers diffusion of a marker with concentration $c(x,y,t)$ across a liver lobule. The lobule is patterned into a central zone around the central vein (center of simulation domain) and portal zones around (here six) portal triads that here act as sinks ($c = 0$).

Spatio-temporal model of planar polarity regulation during planarian regeneration Introduction This simulation reproduces Figure 4D of the referenced paper. Parameter values correspond to the β-catenin-1(RNAi) pattern as given in Table S2 of the referenced paper.

Spatio-temporal model of planar polarity regulation during planarian regeneration Introduction This simulation reproduces Figure 4C of the referenced paper. Parameter values correspond to the wild type pattern (control) as given in Table S2 of the referenced paper.

Mutual Zonated Interactions of Wnt and Hh Signaling Are Orchestrating the Metabolism of the Adult Liver in Mice and Human Reference This model is described in the peer-reviewed publication: